A. Gerisch, S. Tiburtius, Q. Grimal, and K. Raum
Technische Universität Darmstadt, Darmstadt, Germany
Laboratoire d’Imagerie Paramétrique, UPMC, Paris, France
Julius Wolff Institut & Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany
Musculoskeletal mineralized tissues (MMTs), e.g. bone, are hierarchical composite materials. Their effective elastic properties at different scales are of interest for computational studies of the MMT’s response to mechanical loading but also to realistically simulate implant osseointegration. We combine multi-scale and multi-modal experimental techniques with mathematical modelling of MMTs ...
D. Iber, J. Vollmer, D. Menshykau
Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland
Most models of biological pattern formation are simulated on continuous domains even though cells are discrete objects that provide internal boundaries to the diffusion of regulatory components. In our previous papers on simulating organogenesis in COMSOL Multiphysics® (Germann et al COMSOL Multiphysics® Conf Procedings 2011; Menshykau and Iber, COMSOL Multiphysics® Conf Proceedings 2012) we ...
An Assessment of the Suitability of the Body and Adult Head Coils for Transmission during Paediatric Magnetic Resonance Imaging
G.R. Cook, M.J. Graves, F.J. Robb, D.J. Lomas
Department of Radiology, University of Cambridge, Cambridge, United Kingdom
General Electric Healthcare Coils, Aurora, Ohio, USA
MRI offers many advantages over other modalities and its lack of ionizing radiation is important for children, but can be limited by the radio-frequency (RF) coils available. This work calculates Specific Absorption Rate (SAR) and homogeneity of the RF transmit field (B1+) when imaging infants in adult coils. Two birdcage-type coils were loaded by a tissue model and their B1+ homogeneities ...
L. Garber[1,2], G. S. B. Williams, W. J. Lederer
Fischell Department of Bioengineering, University of Maryland, Baltimore, MD, USA
Center for Biomedical Engineering & Technology, University of Maryland, Baltimore, MD, USA
This project involves a simplified biological problem that was used to test the potential of COMSOL Multiphysics® software for cardiac myocyte spatial modeling. We made several assumptions to simplify the biological complexity and to highlight the geometrical structures (i.e., lack of sarcoplasmic reticulum, lack of contractile apparatus). We explored the role of the t-tubular network on ...
J. Anza, and M. Esteves
Department of applied mathematics, University of the Basque Country, Bilbao, Spain
University of the Basque Country, Bilbao, Spain
This work deals with the computer simulation of the blood flow, the arterial wall deformation and their 3D bidirectional interaction, including initial stresses and root displacements. The flow is laminar and steady with flexible walls modeled with a hyperelastic Demiray material model. Poiseuille formula is used to check the bidirectional interaction. 2D axisymmetric and full 3D models have ...
D. Iber, D. Menshykau, and P. Germann
Department of Biosystems Science and Engineering
Organogenesis is a tightly regulated process that has been studied experimentally for decades. Computational models can help to integrate available knowledge and to better understand the underlying regulatory logic. We are currently studying mechanistic models for the development of limbs, lungs, kidneys, and bone. We have tested a number of alternative methods to solve our spatio-temporal ...
E. Bianchi, M.F. Bello, I. Critelli, G. Dubini
Politecnico di Milano, LaBS, Laboratory of Biological Structure Mechanics, Milano, Italy
Swiss Federal Institute of Technology (EPFL), Laboratory of Life Sciences Electronics - Swiss Up Chair, Lausanne, Switzerland
A microfluidic thermal cycler for Polymerase Chain Reaction (PCR) has been modeled. A microliter sample is driven along the microchannel by a flow generated by means of electroosmotic micropumps, activated in sequence. Several multichannel pumps configurations have been separately modeled and the efficiency of each device has been evaluated with regard to the effective flowrate and the back ...
A Simplified Numerical Model for Simulating Sliding Door and Surgical Staff Movement in an Operating Theater
Dipartimento di Energetica, Università di Firenze, Firenze, Italy
This paper deals with a numerical investigation on sliding door and people moving effects on the indoor climate of a standard ISO5 class OT with an ultraclean air filter system and a total ceiling unidirectional diffuser. A simple method to analyze the effects on the OT climate by different sliding door conditions combined with crossing persons and persons with a stretcher crossing is provided. ...
X. Xu, T. Patel, R.W. Hoyt
U.S. Army Institute of Environmental Medicine, Natick, MA, USA
A human torso model was created for heat transfer analysis. The torso was derived from the ‘Virtual Family’ whole-body voxel data from the ITIS Foundation (Zurich, Switzerland). Measurements were taken from the ITIS male along the axial plane at key anatomical landmarks and used to develop geometry in Solidworks. Individual components were created to represent the skin, fat, muscle, and bone ...
P. Apell, S. Hjalmarsson, T. Lindberg, I. Wernström, Y. Tarakonov, A. Erichsen Andersson, M. Karlsteen
Department of Applied Physics, Chalmers University of Technology, Göteborg, Sweden
Sahlgrenska University Hospital, Department of Anesthesia, Surgery and Intensive Care, Göteborg, Sweden
Patients undergoing surgery are sensitive to infections. The operation staff may spread 10^4 particles per person per minute, of which ten percent are presumed bacteria-carrying. We visualize the influence of the personnel on the air and particle flows for the two most common ventilation systems in Swedish hospitals using Comsol Multiphysics with particle tracing.. The Laminar Air ...