A. Lucantonio, P. Nardinocchi, L. Teresi
Università degli Studi La Sapienza, Roma, Italy
LaMS - Modelling & Simulation Lab, Università degli Studi Roma Tre, Roma, Italy
Polymer gels belong to the realm of soft active materials as they are capable of responding to a non-mechanical stimulus – the permeation of a solvent – with a mechanical action – a volume change, thanks to the coupling between different physics. This mechanism of coupling can be exploited in a wide range of applications, including biomedical devices, making crucial the understanding of the ...
A. Avanzini, D. Battini, M. Berardi
Università degli Studi di Brescia, Brescia, Italy
The complex behavior of biological prosthetic heart valves was simulated. A multiphysics computational approach was adopted using different modules of COMSOL Multiphysics: the LiveLink(TM) interface was used to exchange the valve geometry with CAD, Structural Mechanics Module to set loads, boundary conditions and implement anisotropic hyper-elastic constitutive laws for leaflet tissue, PDE to ...
P. Silva, J.A. Ferreira, P. de Oliveira
Coimbra Institute of Engineering, CMUC, Coimbra, Portugal
Department of Mathematics University of Coimbra, CMUC, Coimbra, Portugal
The aim of the poster is to present a coupled 2D mathematical model to predict the evolution of drug concentration - in the cornea and in the anterior chamber of the eye - when therapeutic lenses are used (Figure 1). The mathematical model takes into account (i) diffusion processes in several compartments of the eye (therapeutic lens, cornea and anterior chamber); (ii) metabolic consuming ...
Simulation of Chemotractant Gradients in Microfluidic Channels to Study Cell Migration Mechanism in Silico
P. Wallin, E. Bernson, J. Gold
Chalmers University of Technology, Applied Physics, Biological Physics, Gothenburg, Sweden
Cell migration of endothelial cells along gradients is an important process in vivo and an interesting target for cancer therapeutics. Microfluidics offer very powerful tools to study such migration processes in detail in the lab. In this study, we describe a model to simulate molecular gradients in a diffusion based microfluidic gradient generator and how a cell senses these gradients via cell ...
H. Chen-Mayer, R.E. Tosh
National Institute of Standards and Technology, Gaithersburg, MD, USA
The radiation dose produced by an x-ray CT scanner to the patient is conventionally referenced to measurements performed by an ionization chamber in a phantom. On a fundamental level, the radiation absorbed dose, J/kg, can be determined directly by the temperature rise in the absorbing material. We model the temperature response in a high density polyethylene (HDPE) phantom. Use of ...
M. Cartas-Ayala, R. Karnik
Massachusetts Institute of Technology, Cambridge, MA, USA
Characterization of particles has numerous applications in science and diagnostics. Recently, particle passage through constrained microchannels has been proposed to characterize particles based on their passage velocity. Nevertheless, there is no clear understanding of how the physics in this system interact. Here we quantify the effects of the flow around the particle by simulating the passage ...
H. Ghosh, C. R. Chaudhuri
Department of Electronics and Telecommunication, BESUS, Howrah, West Bengal, India
In this project, we are aiming towards the development of an impedimetric biosensor based on nanoporous silicon structures for the detection of small molecular size and low weight food toxins (like Aflatoxin). Existing sensors for such toxin detection fail to achieve high sensitivity because Aflatoxin molecules are so small in size that they are unable to cause significant impedance change on ...
A Study on Nutrient Mass Transport through Porous Channeled Flat Sheet Membrane and Prediction of Maximum Scaffold Thickness for Viable Cell Culture (In-vitro) by 3D Modeling for Tissue Engineering Application
N. M. S. Bettahalli, B. J. Papenburg , D. S. Stamatialis , M. Wessling 
University of Twente, Enschede, The Netherlands & BMS College of Engineering, Bangalore, India
University of Twente, Enschede, The Netherlands
RWTH Aachen University
Tissue engineering (TE) is a multidisciplinary field involving principles of engineering and life sciences to improve the health and quality of life by repairing, restoring, maintaining, or enhancing tissue and organ function using cells, scaffolds, and growth factors alone or in combination. There are several artificial tissues that are already being used which include fabricated skin, ...
N. Mane, A. Gaikwad
Department of Instrumentation, Cummins College of Engineering, Pune, Maharashtra, India
Micro electro-mechanical system (MEMS) is rapidly growing area of interest for a broad spectrum of applications. One particularly fast-growing area is biomedical applications for micromaching technologies. One application of interest to the biomedical industry is the development of microneedles. MEMS technology brings new means for biomedicine field. Patch-based transdermal drug delivery offers ...
K. Funamoto, I.K. Zervantonakis, R.D. Kamm
Tohoku University, Sendai City, Miyagi, Japan
Massachusetts Institute of Technology
Numerical simulation of oxygen tension was performed to develop a microfluidic device for three-dimensional real-time observation of cellular response under hypoxia. The optimal experimental condition was obtained through investigations of effects of parameters, such as device thickness and flow rates of media and gas, on oxygen tension.