K. Gandhi ,
 University of California, Riverside, CA, USA
The delivery of chemotherapy for cancer into the central nervous system, in particular the brain, remains a challenge. This results in brain metastases commonly being a cause of death from cancer. Here, we look at the environment of the blood-brain barrier. Then, we explore two proteins (breast cancer resistance protein and p-glycoprotein) that may inhibit the transport of medications (erlotinib ...
Simulating Organogenesis in COMSOL Multiphysics®: Comparison of Methods for Simulating Branching Morphogenesis
L. D. Wittwer , M. Peters , S. Aland , D. Iber ,
 ETH Zürich, Zurich, Switzerland
 University of Applied Sciences, Dresden, Germany
Organogenesis, the genesis of organs during embryonic development, is an active research field involving biologists, mathematicians and computational researchers. Fundamental questions of the formation of shape and the control of growth are still not answered. We focus on the development of the embryonic mouse lung and kidney. From all proposed mechanisms, a Turing Pattern-based framework as ...
A. Chanda, A.R. Choudhury, G. Ray, K. Dasgupta, and D. Nag
Jadavpur University, Kolkata, West Bengal, India
Atherosclerosis in arteries is caused by the formation of stenosis : fatty depositions, on the artery wall. In current medicine, the practice is to observe the maximum percentage occlusion at any arbitrary cross-section and diagnose the patient on that basis, which might not always present the real picture due to non-uniformity of the stenosis thickness. The present work attempts to simulate the ...
P. Pattanaik, S. K. Kamilla, D. P. Das, S. K. Pradhan
MEMS Design Center, Institute of Technical Education & Research (ITER), Sikhya ‘O’ Anushandhan University, Bhubaneswar, Odisha, India
Process Engineering and Instrumentation Lab, Institute of Minerals and Materials Technology (IMMT), Bhubaneswar, Odisha, India
Dept of ECE, Hi-Tech Institute of Technology, Khurda, Odisha, India
This paper describes the design of an ultrasonic transducer using different lead free piezo-electric materials and evaluates their performance with different glucose levels in the human blood. COMSOL Multiphysics 4.2a was used for the simulation study using 2D axis symmetric model of piezoelectric transducer which was designed with lead free piezoelectric materials such as Barium Sodium Niobate ...
Investigation of the Effect of Spinal Defects on Spondylolysis and Stress Fracture of Vertebral Bodies
M.S. Yeoman, C. Quah, A. Cizinauskas, K. Cooper, D. McNally, B. Boszczyk
Continuum Blue, Tredomen, Ystrad Mynach, United Kingdom
The Centre for Spinal Studies and Surgery, Queen’s Medical Centre, Nottingham, United Kingdom
Bioengineering Research Group, Faculty of Engineering, The University of Nottingham, Nottingham, United Kingdom
Spondylolysis (SL) is a defect of the spinal vertebra, and is typically caused by stress fracture of the pars interarticularis bone of the vertebral arch. It is especially common in adolescents who over train in sporting activities. Spina bifida occulta (SBO) is a malformation of the spine where the protruding vertebral bodies are not fully formed. In this study we demonstrate the predisposition ...
J. C. Kumaradas, A. Zhang, Y. D. Davletshin
Ryerson University, Toronto, ON, Canada
University of Waterloo, Waterloo, ON, Canada
Tremendous progress is being made in the integration of nanoparticles into micro-analytical systems for biosensing. These materials are shown to enhance the analyte capture capability of biosensing platforms. We have implemented a computational model that considers the sensor’s geometry, size, analyte concentration and type to predict the number of nucleic acid molecules captured by ...
Simulation and Experimental Analysis of Drug Release Rates from Magnetic Nanocomposite Spheres - new
L. Saeeednia, H. Mehraein, F. Abedin, K. Cluff, R. Asmatulu
Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA
Department of Bioengineering, Wichita State University, Wichita, KS, USA
Targeted drug delivery systems have been wildly studied in cancer therapy due to the toxicity of most of chemotherapeutic drugs. Nanoparticles can be attached to the small molecules of the drugs and serve as drug carriers to deliver the drug molecules into the area of interest. In this research, polymeric microspheres containing biodegradable poly(D, L-lactide-co-glycolide) (PLGA), magnetic ...
P. Wijdenes , H. Ali , N. Syed , C. Dalton ,
 Centre for Bioengineering Research and Education, University of Calgary, Calgary, AB, Canada
 Department of Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
 Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada
Our inability to record single cell activity with high resolution over a long period of time precludes fundamental understanding of nervous system functions, both under normal and pathological conditions. While the fabrication of current micro- and nano-electrodes has advanced our capabilities to perform long-term recordings, this has been at the expense of signal resolution due to low sealing ...
K. Carlson , J. Arle , J. L. Shils , L. Mei ,
 Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA
 Rush Medical Center, Chicago, IL, USA
In 1901 Weiss proposed an equation predicting activation of nerve fibers by electrical stimulation, used in neuroscience and neuromodulation, which applies electric fields to modify nerve behavior in neurological disorders. Weiss’ equation is relative to geometry, electrode array, tissue conductivities, and waveform since it uses electrode amplitude. We replicated a leading calibrated nerve ...
Influence of Non-Newtonian Blood Viscosity on Wall Pressure in Right Coronary Arteries with Serial Stenoses
B. Liu 
 Monmouth University, West Long Branch, NJ, USA
Three dimensional mathematical models are developed to simulate the blood flows in patient specific right coronary arteries with two stenoses. Simulations are carried out with various flow parameters under physiological conditions. Both Newtonian and non-Newtonian blood viscosity models are applied in the simulations to examine the influence of non-Newtonian viscosity of blood on the wall ...