G. Zhang, Y. Zhao, J. Brcka, J. Faguet, E. Lee
Clemson University, Clemson, SC, USA
TEL U.S. Holdings, Inc., U.S. Technology Development Center, Austin, TX, USA
In our experiments with manipulating cells with DEP, we noted that some cells are constantly spining. By hypothesing that the cell spining is caused by the non-circular shape of the cell body and the off-centered location of its nucleus and that the rotation direction depends on the relative location of nucleus with respect to the electrical field, we found that the observed cell rotation was ...
V. Tidwell, P. LaRosa, M. Zhang, H. Eswaran, A. Nehorai
Department of Electrical & Systems Engineering, Washington University in St. Louis, St. Louis, MO, USA
Monsanto Company, Technology Pipeline Solutions, St. Louis, MO, USA
OB/GYN Department, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Uterine contractions during pregnancy are currently poorly understood – experts disagree on the mechanisms by which contractions propagate through the organ and the structural layout of the uterine muscle fibers. We have developed a multi-scale model of the uterus, at the cellular, tissue, and organ levels. By comparing simulated abdomen-level magnetic field readings from our model to clinical ...
李娜 , 李江红 
研究头部损伤机理是对运动撞击中脑损伤进行预测的有效手段。数学模型是分析损伤实验数据、预测人员碰撞损伤程度的唯一方法，但现有的头部损伤有限元模型基于尸体实验数据，且忽略脑组织结构的各向异性。本项目旨在提出并实现一种以损伤生物力学为基础、结合磁共振扫描 DTI 的轴突走向信息的有限元力学模型。提取脑外伤前的弥散张量成像信息，实现深入到轴突水平有限元力学模型的建立，在有限元模拟中采用非线性超弹性力学模型，并植入 NSGAII 最优化方法对有限元模型的材料参数进行优化，从而提高模型的稳定性和计算精度；将计算预测结果与损伤后 DTI 的 FA 值所表现的轴突断裂情况进行验证， 探索活体环境下碰撞损伤中脑轴突的损伤性变化，从而获得脑外伤损伤程度与力学因素之间的关系，为脑外伤损伤程度的预测和脑外伤损伤标准的校正提供精确完整的信息。本项目的研究成果将在汽车碰撞的乘员防护设计上有重要的理论指导价值。 ...
P. Wijdenes , H. Ali , N. Syed , C. Dalton ,
 Centre for Bioengineering Research and Education, University of Calgary, Calgary, AB, Canada
 Department of Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
 Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada
Our inability to record single cell activity with high resolution over a long period of time precludes fundamental understanding of nervous system functions, both under normal and pathological conditions. While the fabrication of current micro- and nano-electrodes has advanced our capabilities to perform long-term recordings, this has been at the expense of signal resolution due to low sealing ...
S. Sridhar , T. J. Akl ,
 Analog Devices Inc., Wilmington, MA, USA
Electrodermal Activity (EDA) is a measure of changes in the conductivity of the skin. It has have been found to be indicative of the individual’s autonomic nervous activity which is correlated to their stress and emotional state. These conductivity changes are tracked by injecting a small electric current directly into the skin and measuring the induced voltage drop over time. With increase in ...
Inlay Fixed Partial Denture Framework 3-D Structural Integrity Validation Using COMSOL Multiphysics®
Department of Electrical Engineering and Automation, University of Vaasa, Vaasa, Finland
Manual manufacturing of inlay fixed partial denture frameworks by metal casting can take hours of dental practitioners work time. This paper introduces 3-D simulations of premanufactured inlay fixed partial denture framework assembled from laser cut sheet metal parts. The study gives a good estimation of how well the frameworks can withstand strong human occlusion forces and masticatory cycle. ...
A. González-Suárez, M. Trujillo, J. Koruth, A. D'Avila, E. Berjano
Biomedical Synergy, Electronic Engineering Department,Universitat Politècnica de Valencia, Valencia, Spain
Instituto Universitario de Matemática Pura y Aplicada, Universitat Politècnica de Valencia, Valencia, Spain
Helmsley Cardiac Electrophysiology Center, Mt SinaiMedicalCenter and School of Medicine, New York, NY, USA
Previous studies proposed using bipolar radiofrequency ablation across two catheters placed on opposing surfaces of the ventricular wall to create transmural lesions. 2D and 3D models were built and solved with COMSOL Multiphysics software. With these models, it was possible to study the temperature distribution and lesion geometry (Figure), to compare the potential of two ways of applying ...
Laser Interstitial Thermo Therapy (LITT) for Prostate Cancer Animal Model: Numerical Simulation of Temperature and Damage Distribution
M.F. Marqa, P. Colin, P. Nevoux, S. Mordon, and N. Betrouni
University of Lille, CHRU, Lille, France
Laser interstitial thermotherapy (LITT) is a cancer treatment technique in which laser fibers are introduced inside the tumor. While it destroys deep tumors, the LITT procedure allows minimizing the impact on adjacent healthy structures. One of the effective methods to perform treatment planning for LITT is simulation. We used COMSOL Multiphysics to simulate the heat distribution and thermal ...
The Effect of Cartilaginous Rings on Deposition by Convection, Brownian Diffusion and Electrostatics
Luleå University of Technology, Luleå, Sweden
This paper presents a numerical study of the deposition of spherical charged nanoparticles caused by convection and Brownian diffusion in a pipe with a cartilaginous ring structure. The model is supposed to describe deposition of charged particles in the upper generations of the tracheobronchial tree of the human lung. The upper airways are characterized by a certain wall structure called ...
J. C. Kumaradas, A. Zhang, Y. D. Davletshin
Ryerson University, Toronto, ON, Canada
University of Waterloo, Waterloo, ON, Canada
Tremendous progress is being made in the integration of nanoparticles into micro-analytical systems for biosensing. These materials are shown to enhance the analyte capture capability of biosensing platforms. We have implemented a computational model that considers the sensor’s geometry, size, analyte concentration and type to predict the number of nucleic acid molecules captured by ...